Our ClearCell® FX1 System

Our ClearCell® FX1 System is a fully automated device for cell retrieval that can separate and enrich wholly intact and viable CTCs from small amounts of blood. It is driven by our CTChip® FR1 biochip.

Our CTChip® FR1 biochip is a single-use microfluidic biochip that enriches CTCs based on size and response to inertial forces, through a process called Dean Flow Fractionation. When a blood sample is passed through the microfluidic channel of our CTChip® FR1 biochip, inertial lift forces and Dean flows cause differently-sized cells in the blood sample to separate and distribute themselves within channels, with the larger cells along the inner wall and the smaller cells away from the inner wall. In this way, based on difference in cell size, CTCs (which are relatively larger in diameter) can be separated from leukocytes.


Our ClearCell® FX1 System

Our ClearCell® FX1 System is a fully automated device for cell retrieval that can separate and enrich wholly intact and viable CTCs from small amounts of blood. It is driven by our CTChip® FR1 biochip.

Our CTChip® FR1 biochip is a single-use microfluidic biochip that enriches CTCs based on size and response to inertial forces, through a process called Dean Flow Fractionation. When a blood sample is passed through the microfluidic channel of our CTChip® FR1 biochip, inertial lift forces and Dean flows cause differently-sized cells in the blood sample to separate and distribute themselves within channels, with the larger cells along the inner wall and the smaller cells away from the inner wall. In this way, based on difference in cell size, CTCs (which are relatively larger in diameter) can be separated from leukocytes.

Workflow

1. Sample Collection 2. Red Blood Cell Lysis 3. CTC Enrichment 4. Enriched CTC Sample
7.5ml blood sample
is collected


Red blood cell
lysis is performed


CTC enrichment is
performed on the
ClearCell® FX1 System

Enriched CTC output
ready for downstream
analysis

A blood sample is obtained from a patient through a simple blood draw. We first chemically treat the blood sample to lyse (break down) and remove the red blood cells. The sample is then passed through the CTChip® FR1 biochip to isolate the CTCs from leukocytes (white blood cells).

Our ClearCell® FX1 System has been tested and validated for use with human blood samples. It is compatible with most blood collection tubes from various manufacturers. The choice of blood collection tube depends on the intended downstream application, or diagnostic test.

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1. Sample Collection

7.5ml blood sample is collected

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2. Red Blood Cell Lysis

Red blood cell lysis is performed

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3. CTC Enrichment

CTC enrichment is performed on the ClearCell® FX1 System

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4. Enriched CTC Sample

Enriched CTC output ready for downstream analysis

A blood sample is obtained from a patient through a simple blood draw. We first chemically treat the blood sample to lyse (break down) and remove the red blood cells. The sample is then passed through the CTChip® FR1 biochip to isolate the CTCs from leukocytes (white blood cells).

Our ClearCell® FX1 System has been tested and validated for use with human blood samples. It is compatible with most blood collection tubes from various manufacturers. The choice of blood collection tube depends on the intended downstream application, or diagnostic test.